Hydrochloric Acid → HCID 10277550, compound

Participants

Reaction Steps

HCl gas was bubbled for 50 minutes through a solution of tert-butyl (1R)-2-((2S)-2-{[(2-amino-5,6,7,8-tetrahydro-6-quinazolinyl)amino]carbonyl}pyrrolidinyl)-1-benzyl-2-oxoethylcarbamate (240 mg, 0.47 mmol) in 15 mL of anhydrous acetic acid at room temperature. Acetic acid was evaporated under reduced pressure and the residue was triturated several times with diethyl ether to yield 141 mg (62%) of the title compound as a white solid.

Provenance & Evidence