Hydrochloric Acid → HCID 10277550, compound

HRID 2216318Notes

Reaction equation

HRID 2216318 reaction equation
[ClH:1].[NH2:2][C:3]1[N:12]=[CH:11][C:10]2[CH2:9][CH:8]([NH:13][C:14]([C@@H:16]3[CH2:20][CH2:19][CH2:18][N:17]3[C:21](=[O:38])[C@H:22]([NH:30]C(=O)OC(C)(C)C)[CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)=[O:15])[CH2:7][CH2:6][C:5]=2[N:4]=1>C(O)(=O)C>[ClH:1].[ClH:1].[NH2:30][C@H:22]([CH2:23][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)[C:21]([N:17]1[CH2:18][CH2:19][CH2:20][C@H:16]1[C:14]([NH:13][CH:8]1[CH2:7][CH2:6][C:5]2[N:4]=[C:3]([NH2:2])[N:12]=[CH:11][C:10]=2[CH2:9]1)=[O:15])=[O:38]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10142183HCID 10142183, compound

Product 1

HCID 10277550HCID 10277550, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

HCl gas was bubbled for 50 minutes through a solution of tert-butyl (1R)-2-((2S)-2-{[(2-amino-5,6,7,8-tetrahydro-6-quinazolinyl)amino]carbonyl}pyrrolidinyl)-1-benzyl-2-oxoethylcarbamate (240 mg, 0.47 mmol) in 15 mL of anhydrous acetic acid at room temperature. Acetic acid was evaporated under reduced pressure and the residue was triturated several times with diethyl ether to yield 141 mg (62%) of the title compound as a white solid.

Workup

  1. customAcetic acid was evaporated under reduced pressure
  2. customthe residue was triturated several times with diethyl ether

Sources & evidence

ORD record
ord-89e485b225894905b2b9f9b16ac10549
Source dataset
uspto-grants-2006_09
Patent number
US07112590B2

Reaction notes

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