Boc-D-phe-pro-OH → Tert-butyl (1r)-1-benzyl-2-oxo-2-{(2s)-2-[(4,5,6,7-tetrahydro-2h-indazol-5-ylamino)carbonyl]pyrrolidinyl}ethylcarbamate

HRID 2216319Notes

Reaction equation

HRID 2216319 reaction equation
[NH:1]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[C@@H:2]([C:10]([N:12]1[CH2:19][CH2:18][CH2:17][C@H:13]1[C:14](O)=[O:15])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl.Cl.[NH2:29][CH:30]1[CH2:38][CH2:37][C:36]2[C:32](=[CH:33][NH:34][N:35]=2)[CH2:31]1>>[CH2:3]([C@@H:2]([NH:1][C:20](=[O:21])[O:22][C:23]([CH3:26])([CH3:24])[CH3:25])[C:10](=[O:11])[N:12]1[CH2:19][CH2:18][CH2:17][C@H:13]1[C:14]([NH:29][CH:30]1[CH2:38][CH2:37][C:36]2[C:32](=[CH:33][NH:34][N:35]=2)[CH2:31]1)=[O:15])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 1797945Boc-D-phe-pro-OHHCID 1784786534,5,6,7-tetrahydro-1H-indazol-5-amine dihydrochloride

Product 1

HCID 178454148Tert-butyl (1r)-1-benzyl-2-oxo-2-{(2s)-2-[(4,5,6,7-tetrahydro-2h-indazol-5-ylamino)carbonyl]pyrrolidinyl}ethylcarbamateYield 80%

Procedure

The title compound was prepared from Boc-D-PheL-Pro-OH and 5-amino-4,5,6,7-tetrahydro-2H-indazole dihydrochloride using the procedure of EXAMPLE 6, and was obtained as a white solid.

Workup

  1. customwas obtained as a white solid

Sources & evidence

ORD record
ord-b1fb6d9cdfde4cfdb0f53dbe65797b0b
Source dataset
uspto-grants-2006_09
Patent number
US07112590B2

Reaction notes

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