2,6-Dibromopyridine → 2-Bromo-6-methoxypyridine

While heating under stirring a mixture of 200 g of 2,6-dibromopyridine and 150 ml of methanol on an oil bath at 80° C., 250 ml of a 28% sodium methoxide/methanol solution was added dropwise slowly. The mixture was heated under stirring as it was for 2 hours, and after standing to cool, it was extracted with diethyl ether-water. The organic layer was washed with water and brine, and then dried over anhydrous magnesium sulfate. The solvent was removed, to give 150 g of the title compound.

1. temperatureWhile heating
2. temperatureThe mixture was heated
3. stirringunder stirring as it
4. temperatureto cool
5. extractionit was extracted with diethyl ether-water
6. washThe organic layer was washed with water and brine
7. dry with materialdried over anhydrous magnesium sulfate
8. customThe solvent was removed

ORD record

ord-ba5df9d554594f91a22e0d32480b3724

Source dataset

uspto-grants-2006_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07112593B2