Epibromohydrin → 2-((2-Fluoro-4-methoxyphenoxy)methyl)oxirane

HRID 221635Notes

Reaction equation

HRID 221635 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[OH:10].[CH2:11]([CH:13]1[O:15][CH2:14]1)Br>>[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[O:10][CH2:11][CH:13]1[CH2:14][O:15]1

Participants

3

Reactant 2

HCID 18430EpibromohydrinHCID 27745572-Fluoro-4-methoxyphenol

Product 1

HCID 866236032-((2-Fluoro-4-methoxyphenoxy)methyl)oxiraneYield 48%

Procedure

Synthesis followed SP3a, using 3.5 mmol 2-fluoro-4-methoxyphenol and racemic epibromohydrine to give the title compound upon purification by Flash Master Personal (20 g silica gel cartridge, PE to PE/ethyl acetate 5:1) with 48% yield.

Workup

  1. customSynthesis

Sources & evidence

ORD record
ord-ce62dc3b86b54a8f82fc0eec6e4631f0
Source dataset
uspto-grants-2012_06
Patent number
US08207174B2

Reaction notes

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