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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 221635Generated: October 25, 2026

Epibromohydrin → 2-((2-Fluoro-4-methoxyphenoxy)methyl)oxirane

https://huagongshe.com/reaction/221635

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEpibromohydrinHCID 18430—
Reactant2-Fluoro-4-methoxyphenolHCID 2774557—
Product2-((2-Fluoro-4-methoxyphenoxy)methyl)oxiraneHCID 8662360348%

Reaction Steps

Synthesis followed SP3a, using 3.5 mmol 2-fluoro-4-methoxyphenol and racemic epibromohydrine to give the title compound upon purification by Flash Master Personal (20 g silica gel cartridge, PE to PE/ethyl acetate 5:1) with 48% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08207174B2
Source datasetuspto-grants-2012_06
ORD IDord-ce62dc3b86b54a8f82fc0eec6e4631f0
Source noteuspto-grants-2012_06