Methyl iodide → HCID 69362928, compound

HRID 2216357Notes

Reaction equation

HRID 2216357 reaction equation
[H-].[Na+].I[CH3:4].[CH2:5]([C:12]1[CH:13]=[C:14]([N:18]2[CH2:22][C@H:21]([OH:23])[C@H:20]([OH:24])[CH2:19]2)[CH:15]=[CH:16][CH:17]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>>[CH2:5]([C:12]1[CH:13]=[C:14]([N:18]2[CH2:22][C@H:21]([O:23][CH3:4])[C@H:20]([OH:24])[CH2:19]2)[CH:15]=[CH:16][CH:17]=1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 69363153HCID 69363153, compound

Product 1

HCID 69362928HCID 69362928, compound

Procedure

This was synthesized in the same manner as in Production Example 11 except that 1 equivalent of each of sodium hydride and iodomethane were used to (3R,4S)-1-(3-Benzylphenyl)-3,4-dihydroxypyrrolidine (Production Example 10).

Sources & evidence

ORD record
ord-9fd876c05fd5480682c93856e47830d9
Source dataset
uspto-grants-2006_09
Patent number
US07112593B2

Reaction notes

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