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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2216389Generated: November 1, 2026

Piperidin-4-ol → 5-Amino-2-(4-hydroxypiperidin-1-yl)benzonitrile

https://huagongshe.com/reaction/2216389

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPiperidin-4-olHCID 79341—
Reactant2-Chloro-5-nitrobenzonitrileHCID 85504—
Product5-Amino-2-(4-hydroxypiperidin-1-yl)benzonitrileHCID 2194231358.4%

Reaction Steps

By the reaction and treatment in the same manner as in Starting Material Synthetic Example 4 using 2-chloro-5-nitrobenzonitrile (36 g) and 4-hydroxypiperidine (50 g), the title compound (25 g) was obtained. melting point: 144-145° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07112594B2
Source datasetuspto-grants-2006_09
ORD IDord-a1de5940683f4b788f4d9104a4f34581
Source noteuspto-grants-2006_09