Piperidin-4-ol → 5-Amino-2-(4-hydroxypiperidin-1-yl)benzonitrile

HRID 2216389Notes

Reaction equation

HRID 2216389 reaction equation
Cl[C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-])=O)=[CH:6][C:3]=1[C:4]#[N:5].[OH:13][CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>>[NH2:10][C:7]1[CH:8]=[CH:9][C:2]([N:17]2[CH2:18][CH2:19][CH:14]([OH:13])[CH2:15][CH2:16]2)=[C:3]([CH:6]=1)[C:4]#[N:5]

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 855042-Chloro-5-nitrobenzonitrile

Product 1

HCID 219423135-Amino-2-(4-hydroxypiperidin-1-yl)benzonitrileYield 58.4%

Procedure

By the reaction and treatment in the same manner as in Starting Material Synthetic Example 4 using 2-chloro-5-nitrobenzonitrile (36 g) and 4-hydroxypiperidine (50 g), the title compound (25 g) was obtained. melting point: 144-145° C.

Workup

  1. customBy the reaction and treatment in the same manner as

Sources & evidence

ORD record
ord-a1de5940683f4b788f4d9104a4f34581
Source dataset
uspto-grants-2006_09
Patent number
US07112594B2

Reaction notes

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