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HRID221639

反应详情

EQUATION

反应方程式

HRID 221639 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)[Si](C)(C)Oc1ccc(OCC2CO2)cc1
HCID19385012

未命名化合物

结构：Cc1csc2ncnc(N3CCC(N)CC3)c12
HCID69042395

未命名化合物

PRODUCTS

生成物

1
结构：Cc1csc2ncnc(N3CCC(NCC(O)COc4ccc(O)cc4)CC3)c12
HCID24936488

未命名化合物

收率 11%

PROCEDURE

实验过程

Synthesis followed SP6 (3 h), using 150 μmol tert-butyldimethyl(4-(oxiran-2-ylmethoxy)phenoxy)silane and 1-(5-methylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-amine to give O-silylated intermediate upon purification by prep. HPLC (reversed phase) with 11% yield. Product was obtained by deprotection according to SP7 and purification by prep. HPLC (reversed phase) with 76% yield.

WORKUP

后处理

  1. customSynthesis
  2. customSP6 (3 h)
  3. customto give O-silylated intermediate
  4. customupon purification by prep
  5. customProduct was obtained by deprotection
  6. customaccording to SP7 and purification by prep