Tert-butyldimethyl(4-(oxiran-2-ylmethoxy)phenoxy)silane → 4-(2-Hydroxy-3-(1-(5-methylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-ylamino)propoxy)phenol

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Tert-butyldimethyl(4-(oxiran-2-ylmethoxy)phenoxy)silane	HCID 19385012	—
Edukt	1-(5-Methylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-amine	HCID 69042395	—
Produkt	4-(2-Hydroxy-3-(1-(5-methylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-ylamino)propoxy)phenol	HCID 24936488	11%

Reaktionsschritte

Synthesis followed SP6 (3 h), using 150 μmol tert-butyldimethyl(4-(oxiran-2-ylmethoxy)phenoxy)silane and 1-(5-methylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-amine to give O-silylated intermediate upon purification by prep. HPLC (reversed phase) with 11% yield. Product was obtained by deprotection according to SP7 and purification by prep. HPLC (reversed phase) with 76% yield.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08207174B2
Quelldatensatz	uspto-grants-2012_06
ORD ID	ord-27cfaed441b647929fcf043d52e6a63c
Quellennotiz	uspto-grants-2012_06