1-Benzylpiperidin-4-ol → 5-Amino-2-(1-benzylpiperidin-4-yloxy)benzonitrile

HRID 2216395Notes

Reaction equation

HRID 2216395 reaction equation
Cl[C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-])=O)=[CH:6][C:3]=1[C:4]#[N:5].[CH2:13]([N:20]1[CH2:25][CH2:24][CH:23]([OH:26])[CH2:22][CH2:21]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[NH2:10][C:7]1[CH:8]=[CH:9][C:2]([O:26][CH:23]2[CH2:24][CH2:25][N:20]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:21][CH2:22]2)=[C:3]([CH:6]=1)[C:4]#[N:5]

Participants

3

Reactant 2

HCID 784611-Benzylpiperidin-4-olHCID 855042-Chloro-5-nitrobenzonitrile

Product 1

HCID 219423525-Amino-2-(1-benzylpiperidin-4-yloxy)benzonitrileYield 41.6%

Procedure

By the reaction and treatment in the same manner as in Starting Material Synthetic Example 4 using 2-chloro-5-nitrobenzonitrile (10 g) and 1-benzyl-4-hydroxypiperidine (11.5 g), the title compound (7 g) was obtained as an oil.

Workup

  1. customBy the reaction and treatment in the same manner as

Sources & evidence

ORD record
ord-dbcfbd5dc67e49a3a10fecd4af8307fa
Source dataset
uspto-grants-2006_09
Patent number
US07112594B2

Reaction notes

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