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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2216395Generated: October 27, 2026

1-Benzylpiperidin-4-ol → 5-Amino-2-(1-benzylpiperidin-4-yloxy)benzonitrile

https://huagongshe.com/reaction/2216395

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Benzylpiperidin-4-olHCID 78461—
Reactant2-Chloro-5-nitrobenzonitrileHCID 85504—
Product5-Amino-2-(1-benzylpiperidin-4-yloxy)benzonitrileHCID 2194235241.6%

Reaction Steps

By the reaction and treatment in the same manner as in Starting Material Synthetic Example 4 using 2-chloro-5-nitrobenzonitrile (10 g) and 1-benzyl-4-hydroxypiperidine (11.5 g), the title compound (7 g) was obtained as an oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07112594B2
Source datasetuspto-grants-2006_09
ORD IDord-dbcfbd5dc67e49a3a10fecd4af8307fa
Source noteuspto-grants-2006_09