5-fluoro-2-methyl-1H-indole-3-carboxylic acid → HCID 21942375, compound

HRID 2216405Notes

Reaction equation

HRID 2216405 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([CH3:11])=[C:5]2[C:12]([OH:14])=O.[NH2:15][C:16]1[CH:17]=[CH:18][C:19]([N:24]2[CH2:29][CH2:28][CH:27]([OH:30])[CH2:26][CH2:25]2)=[C:20]([CH:23]=1)[C:21]#[N:22]>>[C:21]([C:20]1[CH:23]=[C:16]([NH:15][C:12]([C:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([F:1])[CH:3]=3)[NH:7][C:6]=2[CH3:11])=[O:14])[CH:17]=[CH:18][C:19]=1[N:24]1[CH2:29][CH2:28][CH:27]([OH:30])[CH2:26][CH2:25]1)#[N:22]

Participants

3

Reactant 2

HCID 135362755-fluoro-2-methyl-1H-indole-3-carboxylic acidHCID 219423135-Amino-2-(4-hydroxypiperidin-1-yl)benzonitrile

Product 1

HCID 21942375HCID 21942375, compoundYield 32.8%

Procedure

By the reaction and treatment in the same manner as in Example 6 using 5-fluoro-2-methyl-1H-indole-3-carboxylic acid (0.9 g) and 5-amino-2-(4-hydroxypiperidin-1-yl)benzonitrile (1.1 g), the title compound (0.6 g) was obtained. melting point: 169-171° C.

Sources & evidence

ORD record
ord-ec993d54c224478b800ec7bc55bb052f
Source dataset
uspto-grants-2006_09
Patent number
US07112594B2

Reaction notes

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