5-fluoro-2-methyl-1H-indole-3-carboxylic acid → N-(3-cyano-4-neopentyloxyphenyl)-5-fluoro-2-methyl-1H-indole-3-carboxamide
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([CH3:11])=[C:5]2[C:12]([OH:14])=O.[NH2:15][C:16]1[CH:17]=[CH:18][C:19]([O:24][CH2:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[C:20]([CH:23]=1)[C:21]#[N:22]>>[C:21]([C:20]1[CH:23]=[C:16]([NH:15][C:12]([C:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([F:1])[CH:3]=3)[NH:7][C:6]=2[CH3:11])=[O:14])[CH:17]=[CH:18][C:19]=1[O:24][CH2:25][C:26]([CH3:28])([CH3:27])[CH3:29])#[N:22]Participants
3
Procedure
By the reaction and treatment in the same manner as in Example 6 using 5-fluoro-2-methyl-1H-indole-3-carboxylic acid (1 g) and 5-amino-2-neopentyloxybenzonitrile (1.1 g), the title compound (0.6 g) was obtained. melting point: 169-171° C.
Sources & evidence
- ORD record
- ord-fd462512718f439c9095a03b43e23c62
- Source dataset
- uspto-grants-2006_09
- Patent number
- US07112594B2
Reaction notes
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