HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-fluoro-2-methyl-1H-indole-3-carboxylic acid → N-(3-cyano-4-neopentyloxyphenyl)-5-fluoro-2-methyl-1H-indole-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-fluoro-2-methyl-1H-indole-3-carboxylic acid | HCID 13536275 | — |
| Reactant | 5-Amino-2-neopentyloxybenzonitrile | HCID 17822734 | — |
| Product | N-(3-cyano-4-neopentyloxyphenyl)-5-fluoro-2-methyl-1H-indole-3-carboxamide | HCID 21058042 | 30.5% |
Reaction Steps
By the reaction and treatment in the same manner as in Example 6 using 5-fluoro-2-methyl-1H-indole-3-carboxylic acid (1 g) and 5-amino-2-neopentyloxybenzonitrile (1.1 g), the title compound (0.6 g) was obtained. melting point: 169-171° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07112594B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-fd462512718f439c9095a03b43e23c62 |
| Source note | uspto-grants-2006_09 |