Benzo(b)thiophene-2-carboxylic acid → HCID 21942334, compound

HRID 2216409Notes

Reaction equation

HRID 2216409 reaction equation
[S:1]1[C:5]([C:6]([OH:8])=O)=[CH:4][C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]1=2.[NH2:13][C:14]1[CH:15]=[CH:16][C:17]([N:22]2[CH2:27][CH2:26][CH:25]([OH:28])[CH2:24][CH2:23]2)=[C:18]([CH:21]=1)[C:19]#[N:20]>>[C:19]([C:18]1[CH:21]=[C:14]([NH:13][C:6]([C:5]2[S:1][C:2]3[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=3[CH:4]=2)=[O:8])[CH:15]=[CH:16][C:17]=1[N:22]1[CH2:27][CH2:26][CH:25]([OH:28])[CH2:24][CH2:23]1)#[N:20]

Participants

3

Reactant 2

HCID 95864Benzo(b)thiophene-2-carboxylic acidHCID 219423135-Amino-2-(4-hydroxypiperidin-1-yl)benzonitrile

Product 1

HCID 21942334HCID 21942334, compoundYield 40.3%

Procedure

By the reaction and treatment in the same manner as in Example 6 using benzo[b]thiophene-2-carboxylic acid (4 g) and 5-amino-2-(4-hydroxypiperidin-1-yl)benzonitrile (4 g), the title compound (2.8 g) was obtained. melting point: 224-225° C.

Sources & evidence

ORD record
ord-5437f3b240ad4c38856c5b3d818639cd
Source dataset
uspto-grants-2006_09
Patent number
US07112594B2

Reaction notes

Loading…