3-Chloro-1-benzothiophene-2-carboxylic acid → HCID 21942357, compound

HRID 2216417Notes

Reaction equation

HRID 2216417 reaction equation
[Cl:1][C:2]1[C:3]2[CH:13]=[CH:12][CH:11]=[CH:10][C:4]=2[S:5][C:6]=1[C:7]([OH:9])=O.[NH2:14][C:15]1[CH:16]=[CH:17][C:18]([N:23]2[CH2:28][CH2:27][CH:26]([N:29]3[CH2:34][CH2:33][O:32][CH2:31][CH2:30]3)[CH2:25][CH2:24]2)=[C:19]([CH:22]=1)[C:20]#[N:21]>>[Cl:1][C:2]1[C:3]2[CH:13]=[CH:12][CH:11]=[CH:10][C:4]=2[S:5][C:6]=1[C:7]([NH:14][C:15]1[CH:16]=[CH:17][C:18]([N:23]2[CH2:28][CH2:27][CH:26]([N:29]3[CH2:30][CH2:31][O:32][CH2:33][CH2:34]3)[CH2:25][CH2:24]2)=[C:19]([C:20]#[N:21])[CH:22]=1)=[O:9]

Participants

3

Reactant 2

HCID 3079643-Chloro-1-benzothiophene-2-carboxylic acidHCID 219423895-Amino-2-(4-morpholinopiperidin-1-yl)benzonitrile

Product 1

HCID 21942357HCID 21942357, compoundYield 52.2%

Procedure

By the reaction and treatment in the same manner as in Example 6 using 3-chlorobenzo[b]thiophene-2-carboxylic acid (1.1 g) and 5-amino-2-(4-morpholinopiperidin-1-yl)benzonitrile (1.5 g), the title compound (1.3 g) was obtained. melting point: 227-228° C.

Sources & evidence

ORD record
ord-1d516ed0f7cf402585309ff3a51c6197
Source dataset
uspto-grants-2006_09
Patent number
US07112594B2

Reaction notes

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