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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2216424Generated: November 1, 2026

Benzo(b)thiophene-2-carboxylic acid → HCID 21942382, compound

https://huagongshe.com/reaction/2216424

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzo(b)thiophene-2-carboxylic acidHCID 95864—
Reactant5-Amino-2-(2,2-dimethyl-3-hydroxypropoxy)benzonitrile monohydrochlorideHCID 21942317—
SolventTriethylamineHCID 8471—
ProductHCID 21942382HCID 2194238230.4%

Reaction Steps

By the reaction and treatment in the same manner as in Example 6 using benzo[b]thiophene-2-carboxylic acid (0.77 g), 5-amino-2-(2,2-dimethyl-3-hydroxypropoxy)benzonitrile monohydrochloride (1.0 g) and triethylamine (0.6 ml), the title compound (0.45 g) was obtained. melting point: 188-189° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07112594B2
Source datasetuspto-grants-2006_09
ORD IDord-99a6e1b5cd92430797eb9850a7f447c7
Source noteuspto-grants-2006_09