Benzo(b)thiophene-2-carboxylic acid → HCID 21942382, compound

HRID 2216424Notes

Reaction equation

HRID 2216424 reaction equation
[S:1]1[C:5]([C:6]([OH:8])=O)=[CH:4][C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]1=2.Cl.[NH2:14][C:15]1[CH:16]=[CH:17][C:18]([O:23][CH2:24][C:25]([CH3:29])([CH3:28])[CH2:26][OH:27])=[C:19]([CH:22]=1)[C:20]#[N:21]>C(N(CC)CC)C>[C:20]([C:19]1[CH:22]=[C:15]([NH:14][C:6]([C:5]2[S:1][C:2]3[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=3[CH:4]=2)=[O:8])[CH:16]=[CH:17][C:18]=1[O:23][CH2:24][C:25]([CH3:28])([CH3:29])[CH2:26][OH:27])#[N:21]

Participants

4

Reactant 2

HCID 95864Benzo(b)thiophene-2-carboxylic acidHCID 219423175-Amino-2-(2,2-dimethyl-3-hydroxypropoxy)benzonitrile monohydrochloride

Product 1

HCID 21942382HCID 21942382, compoundYield 30.4%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

By the reaction and treatment in the same manner as in Example 6 using benzo[b]thiophene-2-carboxylic acid (0.77 g), 5-amino-2-(2,2-dimethyl-3-hydroxypropoxy)benzonitrile monohydrochloride (1.0 g) and triethylamine (0.6 ml), the title compound (0.45 g) was obtained. melting point: 188-189° C.

Sources & evidence

ORD record
ord-99a6e1b5cd92430797eb9850a7f447c7
Source dataset
uspto-grants-2006_09
Patent number
US07112594B2

Reaction notes

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