HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → HCID 178513881, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | HCID 178510704 | HCID 178510704 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178513881 | HCID 178513881 | — |
Reaction Steps
Carboxylic acid 14.4 can be coupled with 5-aminomethyltetrazole 19.1 (available commercially from Dynamit Nobel GmbH, Leverkusen, Germany) using any of a variety of peptide coupling reagents, including EDC and 1-hydroxybenzotriazole in dichloromethane or DMF, to give 1H-tetraazol-5-ylmethyl carboxamide 19.2. Under similar reaction conditions, 14.4 can be coupled with 5-aminotetrazole 19.3 to afford 1H-tetraazol-5-yl carboxamide 19.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07112601B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-243c4dc6ab51451ca5043d6861e15273 |
| Source note | uspto-grants-2006_09 |