1,2-Dichloroethane → HCID 178513881, compound

HRID 2216506Notes

Reaction equation

HRID 2216506 reaction equation
N[CH2:2][C:3]1[NH:7][N:6]=[N:5][N:4]=1.C(Cl)CCl.ON1C2C=CC=CC=2N=N1.C[N:23]([CH:25]=[O:26])C>ClCCl>[NH:7]1[C:3]([CH2:2][C:25]([NH2:23])=[O:26])=[N:4][N:5]=[N:6]1

Participants

6

Reactant 4

HCID 111,2-DichloroethaneHCID 6228DimethylformamideHCID 757711-HydroxybenzotriazoleHCID 178510704HCID 178510704, compound

Product 1

HCID 178513881HCID 178513881, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Carboxylic acid 14.4 can be coupled with 5-aminomethyltetrazole 19.1 (available commercially from Dynamit Nobel GmbH, Leverkusen, Germany) using any of a variety of peptide coupling reagents, including EDC and 1-hydroxybenzotriazole in dichloromethane or DMF, to give 1H-tetraazol-5-ylmethyl carboxamide 19.2. Under similar reaction conditions, 14.4 can be coupled with 5-aminotetrazole 19.3 to afford 1H-tetraazol-5-yl carboxamide 19.4.

Sources & evidence

ORD record
ord-243c4dc6ab51451ca5043d6861e15273
Source dataset
uspto-grants-2006_09
Patent number
US07112601B2

Reaction notes

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