HCID 11384502, compound → HCID 11258624, compound

HRID 2216516Notes

Reaction equation

HRID 2216516 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:19]([CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[N:18]=[C:17](/[CH:26]=[CH:27]/[C:28]([O:30][CH3:31])=[O:29])[CH:16]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C1C=CC=CC=1.[Pd]>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[N:19]([CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[N:18]=[C:17]([CH2:26][CH2:27][C:28]([O:30][CH3:31])=[O:29])[CH:16]=2)=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 11384502HCID 11384502, compound

Product 1

HCID 11258624HCID 11258624, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 241BenzeneSolvent

Procedure

To a solution of methyl ester 2.3 (52 mg, 0.125 mmol) in benzene (5 ml), was added 10 mg of 10% Pd-C. The atmosphere was evacuated and flushed with H2 gas (3×), and the solution stirred for 1.5 h. The mixture was filtered and concentrated to give 52 mg (100%) of 6.1. MS (ESI) 419.4 (M+H+).

Workup

  1. customThe atmosphere was evacuated
  2. customflushed with H2 gas (3×)
  3. filtrationThe mixture was filtered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-33709c8388e144b38926ff59d6f3e4c5
Source dataset
uspto-grants-2006_09
Patent number
US07112601B2

Reaction notes

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