HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[(E)-[1-(2-aminothiazol-4-yl)-2-oxo-2-(2-oxoethylamino)ethylidene]amino]oxy-2-methyl-propanoic acid → 5-[4-(Benzyloxy)phenyl]-4-bromo-1-cyclohexyl-1h-pyrazole-3-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[(E)-[1-(2-aminothiazol-4-yl)-2-oxo-2-(2-oxoethylamino)ethylidene]amino]oxy-2-methyl-propanoic acid | HCID 15956689 | — |
| Reactant | {5-[4-(Benzyloxy)phenyl]-4-bromo-1-cyclohexyl-1h-pyrazol-3-yl}methanol | HCID 21943365 | — |
| Product | 5-[4-(Benzyloxy)phenyl]-4-bromo-1-cyclohexyl-1h-pyrazole-3-carbaldehyde | HCID 21943321 | 82.5% |
Reaction Steps
Aldehyde 8.3 was prepared from 8.2 according to the procedure described above for the preparation aldehyde 2.2. In this example, 8.2 (295 mg, 0.668 mmol) was oxidized to yield 242 mg (82%) of 8.3. MS (ESI) 439.3 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07112601B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-db3ae2023c2c4db186a0d90684d589c5 |
| Source note | uspto-grants-2006_09 |