HCID 11188844, compound → HCID 11420196, compound

Participants

Reaction Steps

Acid 8.7 was prepared from ester 8.6 according to the procedure described above for the preparation acid 2.4. Thus, 8.6 (50 mg, 0.11 mmol) was saponified to yield 46 mg (95%) of 8.7. HRMS (ESI) calc'd for C31H31N2O3, 479.2335, found 479.2343 (MH+); 1H NMR (300 MHz, CDCl3) δ 7.72 (d, J=15.7, 1H), 7.46–7.21 (m, 8H), 7.12–7.08 (m, 4H), 6.97 (d, J=8.7, 2H), 6.60 (d, J=15.7, 1H), 5.06 (s, 2H), 4.04–3.97 (m, 1H), 2.10–1.85 (m, 5H), 1.65 (br s, 1H), 1.33–1.22 (m, 4H).

Provenance & Evidence