Dichloromethane → HCID 58700790, compound

HRID 2216530Notes

Reaction equation

HRID 2216530 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[C:19]([CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)=[CH:18][C:17](/[CH:26]=[C:27](\[CH3:33])/[C:28]([O:30][CH2:31][CH3:32])=[O:29])=[N:16]2)=[CH:11][CH:10]=1)C1C=CC=CC=1.B(Cl)(Cl)Cl.ClCCl>>[CH:20]1([C:19]2[N:15]([C:12]3[CH:11]=[CH:10][C:9]([OH:8])=[CH:14][CH:13]=3)[N:16]=[C:17](/[CH:26]=[C:27](\[CH3:33])/[C:28]([O:30][CH2:31][CH3:32])=[O:29])[CH:18]=2)[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 25135Boron TrichlorideHCID 11351275HCID 11351275, compound

Product 1

HCID 58700790HCID 58700790, compoundYield 100.6%

Procedure

According to the procedure for preparation of 4.3, debenzylation of 10.1 (440 mg, 0.99 mmol) with 1M BCl3 in dichloromethane (4.95 ml, 4.95 mmol) yielded 353 mg (100%) of 10.3. MS (ESI) 355.4 (MH+).

Sources & evidence

ORD record
ord-076d7981c8504120ba307af9c55fe8e0
Source dataset
uspto-grants-2006_09
Patent number
US07112601B2

Reaction notes

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