HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Bromomethyl)-4'-chloro-4-methoxy-1,1'-biphenyl → Methyl (2E)-3-(2-{4-[(4'-chloro-4-methoxy-1,1'-biphenyl-2-yl)methoxy]phenyl}-1-cyclohexyl-1H-imidazol-4-yl)-2-propenoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Bromomethyl)-4'-chloro-4-methoxy-1,1'-biphenyl | HCID 21943338 | — |
| Reactant | Methyl (2E)-3-{2-[4-(hydroxy)phenyl]-1-cyclohexyl-1H-imidazol-4-yl}-2-methyl-2-propenoate | HCID 136341818 | — |
| Product | Methyl (2E)-3-(2-{4-[(4'-chloro-4-methoxy-1,1'-biphenyl-2-yl)methoxy]phenyl}-1-cyclohexyl-1H-imidazol-4-yl)-2-propenoate | HCID 11341937 | 73.2% |
Reaction Steps
According to the procedure for preparation of 4.4, phenol 12.9 (60 mg, 0.184 mmol) was alkylated with (4′-chloro-4-methoxy-1,1′-biphenyl-2-yl)methyl bromide (63 mg, 0.202 mmol), to yield 75 mg (73%) of 12.10. MS (ESI) 557.4 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07112601B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-ee5eae4a1b084888b1ba8fc351c0edeb |
| Source note | uspto-grants-2006_09 |