HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron Trichloride → Ethyl (2E)-3-{2-[4-(hydroxy)phenyl]-1-cyclohexyl-1H-imidazol-4-yl}-2-methyl-2-propenoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron Trichloride | HCID 25135 | — |
| Reactant | Ethyl (2e)-3-{2-[4-(benzyloxy)phenyl]-1-cyclohexyl-1h-imidazol-4-yl}-2-methyl-2-propenoate | HCID 11293723 | — |
| Product | Ethyl (2E)-3-{2-[4-(hydroxy)phenyl]-1-cyclohexyl-1H-imidazol-4-yl}-2-methyl-2-propenoate | HCID 136008555 | 60% |
Reaction Steps
According to the procedure for preparation of 4.3, ester 13.1 (167 mg, 0.376 mmol) was treated with BCl3 (1.88 mmol) to yield 80 mg (60%) of 13.3. MS (ESI) 355.3 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07112601B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-c511b1ee168d4cbcaba853f69bcf3b0e |
| Source note | uspto-grants-2006_09 |