Cyclopropylamine → HCID 21943411, compound

HRID 2216539Notes

Reaction equation

HRID 2216539 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([CH:6]2[O:8][CH2:7]2)=[CH:4][CH:3]=1.[CH:11]1([NH2:14])[CH2:13][CH2:12]1>>[CH:11]1([NH:14][CH2:7][CH:6]([OH:8])[C:5]2[CH:9]=[CH:10][C:2]([Cl:1])=[CH:3][CH:4]=2)[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 1970104-Chlorostyrene oxide

Product 1

HCID 21943411HCID 21943411, compoundYield 54.5%

Procedure

4-Chloro styrene oxide (1.24 g, 8.0 mmol) and 3 ml of cyclopropylamine in methanolic solution were charged into a flask. The flask was sealed and put in a refrigerator for 5–7 days. The solution was concentrated and the residue crystallized from ether, the title compound was obtained as white needle crystals, mp. 100.2–102° C., yield 54.5%.

Workup

  1. customThe flask was sealed
  2. waitput in a refrigerator for 5–7 days
  3. concentrationThe solution was concentrated
  4. customthe residue crystallized from ether

Sources & evidence

ORD record
ord-e39f8eb7f8254aba99c6e82de44a3ebf
Source dataset
uspto-grants-2006_09
Patent number
US07112605B2

Reaction notes

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