Boron trifluoride etherate → HCID 10309887, compound

HRID 2216541Notes

Reaction equation

HRID 2216541 reaction equation
O[C:2]([C:14]1[CH:19]=[CH:18][C:17]([N:20]([CH3:30])[S:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)(=[O:23])=[O:22])=[CH:16][CH:15]=1)([C:5]1[N:6]([CH2:10][CH2:11][O:12][CH3:13])[CH:7]=[CH:8][CH:9]=1)[CH2:3][CH3:4].C([SiH](CC)CC)C.B(F)(F)F.CCOCC>>[CH3:13][O:12][CH2:11][CH2:10][N:6]1[CH:7]=[CH:8][CH:9]=[C:5]1[CH:2]([C:14]1[CH:19]=[CH:18][C:17]([N:20]([CH3:30])[S:21]([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)(=[O:22])=[O:23])=[CH:16][CH:15]=1)[CH2:3][CH3:4]

Participants

4

Reactant 3

HCID 8000Boron trifluoride etherateHCID 12052TriethylsilaneHCID 10238133N-(4-{1-hydroxy-1-[1-(2-methoxyethyl)-1H-pyrrol-2-yl]-propyl}-phenyl)-N-methyl-benzenesulfonamide

Product 1

HCID 10309887HCID 10309887, compound

Procedure

The title compound was prepared from N-(4-{1-hydroxy-1-[1-(2-methoxyethyl)-1H-pyrrol-2-yl]-propyl}-phenyl)-N-methyl-benzenesulfonamide (Example 2) using triethylsilane and boron trifluoride diethyl etherate as described in Example 88 of co-pending application Ser. No. 10/354,922, entitled “Arylsulfonamidobenzylic Compounds” and provided below as Preparative Example B.

Workup

  1. customprovided below as Preparative Example B

Sources & evidence

ORD record
ord-3360d6f65b0c4dd88bc53e861775e8dd
Source dataset
uspto-grants-2006_09
Patent number
US07112606B2

Reaction notes

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