Boron trifluoride etherate → HCID 10216587, compound

HRID 2216542Notes

Reaction equation

HRID 2216542 reaction equation
O[C:2]([C:15]1[CH:20]=[CH:19][C:18]([N:21]([CH3:31])[S:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)(=[O:24])=[O:23])=[CH:17][CH:16]=1)([C:6]1[N:7]([CH2:11][CH2:12][O:13][CH3:14])[CH:8]=[CH:9][CH:10]=1)[CH2:3][CH2:4][CH3:5].C([SiH](CC)CC)C.B(F)(F)F.CCOCC>>[CH3:14][O:13][CH2:12][CH2:11][N:7]1[CH:8]=[CH:9][CH:10]=[C:6]1[CH:2]([C:15]1[CH:16]=[CH:17][C:18]([N:21]([CH3:31])[S:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)(=[O:24])=[O:23])=[CH:19][CH:20]=1)[CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 3

HCID 8000Boron trifluoride etherateHCID 12052TriethylsilaneHCID 10173622HCID 10173622, compound

Product 1

HCID 10216587HCID 10216587, compound

Procedure

The title compound was prepared from N-(4-{1-hydroxy-1-[1-(2-methoxyethyl)-1H-pyrrol-2-yl]-butyl}-phenyl)-N-methyl-benzenesulfonamide (Example 3) using triethylsilane and boron trifluoride diethyl etherate as described in Example 88 of co-pending application Ser. No. 10/354,922, entitled “Arylsulfonamidobenzylic Compounds” and provided below as Preparative Example B.

Workup

  1. customprovided below as Preparative Example B

Sources & evidence

ORD record
ord-1ff27d59fd3947c492d103018e610b1d
Source dataset
uspto-grants-2006_09
Patent number
US07112606B2

Reaction notes

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