反应详情

温度

40 °C

MeOH (2.73 mL) was added to the THF (180 mL) solution of LiBH4 (1.63 g) under a nitrogen atmosphere at room temperature, and then 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid ethyl ester (8.11 g) was added to the suspension and stirred for 2 h at 40° C. The mixture was quenched with 1 mol/L HCl at pH 1 and stirred for 1 h at room temperature. Solid K2CO3 was added to the solution to adjust pH to 8 and the mixture was extracted with AcOEt. The organic layer was dried (MgSO4) and filtered. The filtrate was concentrated under reduced pressure to afford the title compound as brown crystals (4.87 g, 78%).

1. customThe mixture was quenched with 1 mol/L HCl at pH 1
2. stirringstirred for 1 h at room temperature
3. additionSolid K2CO3 was added to the solution
4. extractionthe mixture was extracted with AcOEt
5. dry with materialThe organic layer was dried (MgSO4)
6. filtrationfiltered
7. concentrationThe filtrate was concentrated under reduced pressure