反应详情

Conc. HCl (1.96 mL) and NaNO2 (2.2 g) were added to the H2O (21 mL) solution of DL-pipecolic acid (3.04 g) under a nitrogen atmosphere at 0° C. and stirred for 1 h. The solution was extracted with CH2Cl2 and organic layer was washed with brine. The mixture was dried over Na2SO4 and concentrated under reduced pressure to afford crude (2RS)-1-nitrosopiperidine-2-carboxylic acid as pale yellow crystals.

1. extractionThe solution was extracted with CH2Cl2 and organic layer
2. washwas washed with brine
3. dry with materialThe mixture was dried over Na2SO4
4. concentrationconcentrated under reduced pressure