Potassium Carbonate → 5-Amino-1-methyl-1,6-dihydropyrazin-2(3H)-one

HRID 2216568Notes

Reaction equation

HRID 2216568 reaction equation
Cl.[NH2:2][C:3]1[CH2:8][N:7]([CH3:9])[C:6](=[O:10])[CH2:5][N:4]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[NH2:2][C:3]1[CH2:8][N:7]([CH3:9])[C:6](=[O:10])[CH2:5][N:4]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 219413655-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride

Product 1

HCID 219413665-Amino-1-methyl-1,6-dihydropyrazin-2(3H)-one

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 5-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride (662 mg) in methanol (10 mL) was added 10% potassium carbonate aqueous solution at 0□ and then stirred for 40 min at 0□. The mixture was concentrated under reduced pressure. The residue was triturated with chloroform (18 mL) and methanol (2 mL) at room temperature for 30 min. The precipitate was filtered off and dried in vacuo. The compound was obtained as a pale brown powder (515 mg, quantitative).

Workup

  1. concentrationThe mixture was concentrated under reduced pressure
  2. customThe residue was triturated with chloroform (18 mL) and methanol (2 mL) at room temperature for 30 min
  3. filtrationThe precipitate was filtered off
  4. customdried in vacuo
  5. customThe compound was obtained as a pale brown powder (515 mg, quantitative)

Sources & evidence

ORD record
ord-2c8307f49cac406a9277db72a8f78c75
Source dataset
uspto-grants-2006_09
Patent number
US07112582B2

Reaction notes

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