反应详情

To the stirred solution of 2,3-dihydropyrazolo[5,1-b][1,3]oxazole-6-methanol (2.60 g, 18.5 mmol) in 60 ml of CH3Cl was added 12.9 g of MnO2. Th suspension was refluxed for 1.5 hour under a nitrogen atmosphere. The reaction mixture was filtered through a pad of Celite. The filtrate was concentrated to give yellow oil. The product was purified by chromatography. 2.15 g of the product was obtained (84.3%).

1. temperatureTh suspension was refluxed for 1.5 hour under a nitrogen atmosphere
2. filtrationThe reaction mixture was filtered through a pad of Celite
3. concentrationThe filtrate was concentrated
4. customto give yellow oil
5. customThe product was purified by chromatography