HCID 10167774, compound → HCID 10122013, compound

HRID 2216708Notes

Reaction equation

HRID 2216708 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:40]=[CH:39][C:38]([C:41](=[O:44])[NH:42][CH3:43])=[CH:37][C:9]=2[CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[N:22]([CH:23]4[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]4)[C:21]4[CH:29]=[CH:30][C:31]([C:33]([O:35]C)=[O:34])=[CH:32][C:20]=4[N:19]=3)=[CH:14][CH:13]=2)=[CH:4][CH:3]=1>O1CCCC1>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:40]=[CH:39][C:38]([C:41](=[O:44])[NH:42][CH3:43])=[CH:37][C:9]=2[CH2:10][O:11][C:12]2[CH:13]=[CH:14][C:15]([C:18]3[N:22]([CH:23]4[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]4)[C:21]4[CH:29]=[CH:30][C:31]([C:33]([OH:35])=[O:34])=[CH:32][C:20]=4[N:19]=3)=[CH:16][CH:17]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 10167774HCID 10167774, compound

Product 1

HCID 10122013HCID 10122013, compoundYield 181.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Methyl 2-{4-[2-(4-chlorophenyl)-5-methylcarbamoylbenzyloxy]-phenyl}-1-cyclohexylbenzimidazole-5-carboxylate (150 mg) obtained in Example 247 and tetrahydrofuran (2 ml) were treated in the same manner as in Example 2 to give the title compound (141 mg, yield 90%).

Sources & evidence

ORD record
ord-489253edcb2f4625b5072131e36f179b
Source dataset
uspto-grants-2006_09
Patent number
US07112600B1

Reaction notes

Loading…