反应详情

温度

70 °C

A solution of methyl 3-(allyloxy)-5-cyanbenzoate (1.5 g, 6.9 mmol) in methanol-tetrahydrofuran (1:2, 30 mL) was treated with 0.5 N lithium hydroxide (17 mL, 8.3 mmol). The reaction was stirred at 70° C. for 30 minutes and then the solvent was removed in vacuo. The residue was dissolved in a small amount of water and then acidified (pH ˜4) by the addition of 2N hydrogen chloride. The precipitate was collected and dried to afford 1.0 g (74%) of 3-allyloxy-5-cyanobenzoic acid as a white solid.

1. customthe solvent was removed in vacuo
2. dissolutionThe residue was dissolved in a small amount of water
3. additionby the addition of 2N hydrogen chloride
4. customThe precipitate was collected
5. customdried