HCID 178513423, compound → HCID 9882073, compound

HRID 2216792Notes

Reaction equation

HRID 2216792 reaction equation
[F:1][C:2]1[CH:19]=[CH:18][C:17]([F:20])=[C:16]([F:21])[C:3]=1[C:4]([O:6][NH:7][C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1)=[NH:9])=O>N1C=CC=CC=1>[N:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[C:8]1[N:9]=[C:4]([C:3]2[C:16]([F:21])=[C:17]([F:20])[CH:18]=[CH:19][C:2]=2[F:1])[O:6][N:7]=1

Participants

3

Reactant 1

HCID 178513423HCID 178513423, compound

Product 1

HCID 9882073HCID 9882073, compoundYield 20.3%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of N-[(2,5,6-trifluorobenzoyl)oxy]pyridine-2-carboximidamide (50 mg, 0.169 mmol) in pyridine (0.3 mL) was heated at 115° C. for 17 hours. Standard work up, and silica gel chromatography, afforded 9.5 mg (20%) of 3-(2-pyridyl)-5-(2,5,6-trifluorophenyl)-1,2,4-oxadiazole.

Sources & evidence

ORD record
ord-c0234e9fd4e240e4a6d35792d472ef0a
Source dataset
uspto-grants-2006_09
Patent number
US07112595B2

Reaction notes

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