反应详情

A mixture of 2-propionyl pyridine (0.60 g, 4.42 mmol) and 2-hydrazinobenzoxazole (0.60 g 4.02 mmol) in 25 ml of methanol is refluxed for 24 hours after the addition of 6 drops of glacial acetic acid. The reaction mixture is stored over night in the refrigerator at approximately 5° C. The precipitate is filtered and recrystallized from diisopropyl ether. Yield: 0.68 g (64% of theory).

1. temperatureis refluxed for 24 hours
2. waitThe reaction mixture is stored over night in the refrigerator at approximately 5° C
3. filtrationThe precipitate is filtered
4. customrecrystallized from diisopropyl ether