2-Hydrazinobenzoxazole → 1-(2-Pyridyl)-1-propanone-1-(1,3-benzoxazol-2-yl)hydrazone

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Reaction Steps

A mixture of 2-propionyl pyridine (0.60 g, 4.42 mmol) and 2-hydrazinobenzoxazole (0.60 g 4.02 mmol) in 25 ml of methanol is refluxed for 24 hours after the addition of 6 drops of glacial acetic acid. The reaction mixture is stored over night in the refrigerator at approximately 5° C. The precipitate is filtered and recrystallized from diisopropyl ether. Yield: 0.68 g (64% of theory).

Provenance & Evidence