HCID 21911719, compound → HCID 28807918, compound

HRID 2217173Notes

Reaction equation

HRID 2217173 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][C:10](=[O:29])[CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][N:16](C(OCC2C=CC=CC=2)=O)[CH2:15][CH2:14]1>CO.[Pd]>[CH3:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([CH3:1])[C:3]=1[NH:9][C:10](=[O:29])[CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1

Participants

4

Reactant 1

HCID 21911719HCID 21911719, compound

Product 1

HCID 28807918HCID 28807918, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To N-(2,6-dimethylphenyl)-3-(4-carbobenzyloxypiperazinyl)propanamide (1.3 g) in 10 mL of methanol was added 10% Pd/C, and the mixture was hydrogenated at 30 psi for 24 hours. The mixture was filtered, and the solvent was removed from the filtrate under reduced pressure, to afford N-(2,6-dimethylphenyl)-3-piperazinylpropanamide, a compound of formula (4),which was used without further purification.

Workup

  1. filtrationThe mixture was filtered
  2. customthe solvent was removed from the filtrate under reduced pressure

Sources & evidence

ORD record
ord-4117c3bd965e4fc4859b0284c295f070
Source dataset
uspto-grants-2008_08
Patent number
US07407960B2

Reaction notes

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