反应详情

A mixture of 2-(2,4-dichlorophenyl)benzoxazol-5-ol (6.0 g, 36 mmol), (S)-(+)-epichlorohydrin (3.3 g, 315 mmol) (20 ml, 182 mmol), and potassium carbonate (20 g, 144 mmol) in acetone (100 ml) was heated to reflux and allowed to stir overnight. The solution was allowed to cool and filtered through Celite 512. The filtrate was evaporated under reduced pressure to yield an oil, which was chromatographed on silica gel, eluting with 20% ethyl acetate/hexanes, to yield 5-[((2R)oxiran-2-yl)methoxy]-2-(2,4-dichlorophenyl)benzoxazole as white solid (6.2 g, 28 mmol).

1. temperaturewas heated
2. temperatureto reflux
3. temperatureto cool
4. filtrationfiltered through Celite 512
5. customThe filtrate was evaporated under reduced pressure
6. customto yield an oil, which
7. customwas chromatographed on silica gel
8. washeluting with 20% ethyl acetate/hexanes