Water → HCID 69103055, compound

HRID 2217235Notes

Reaction equation

HRID 2217235 reaction equation
[NH2:1][C:2]1[C:3]([C:22]#[N:23])=[N:4][C:5]([C:14]2[CH:15]=[N:16][C:17]([O:20][CH3:21])=[CH:18][CH:19]=2)=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:7]=1.[OH2:24].[OH-].[Na+]>Br>[NH2:1][C:2]1[C:3]([C:22]([NH2:23])=[O:24])=[N:4][C:5]([C:14]2[CH:15]=[N:16][C:17]([O:20][CH3:21])=[CH:18][CH:19]=2)=[C:6]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:7]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 69102358HCID 69102358, compound

Product 1

HCID 69103055HCID 69103055, compound

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Conditions

Temperature
27.5 °C

Procedure

3-Amino-6-(6-methoxy-3-pyridyl)-5-phenyl-2-pyrazinecarbonitrile (100 mg) was dissolved in 30% hydrogen bromide solution in ACOH (1 ml). The solution was stirred at 25-30° C. for 3 hours. To the solution was added water. The pH of the aqueous mixture was adjusted to 6-7 with 12% aq. NaOH. The crystals were precipitated. The suspension was stirred at 25-30° C. for 3 hours, and stood for 10 hours in refrigerator. The crystals was collected by filtration and dried in vacuo, to give 3-amino-6-(6-methoxy-3-pyridyl)-5-phenyl-2-pyrazinecarboxamide (92.5 mg).

Workup

  1. customThe crystals were precipitated
  2. stirringThe suspension was stirred at 25-30° C. for 3 hours
  3. waitstood for 10 hours in refrigerator
  4. filtrationThe crystals was collected by filtration
  5. customdried in vacuo

Sources & evidence

ORD record
ord-6b2a0a2b3a754791b1a4f472651982d8
Source dataset
uspto-grants-2008_08
Patent number
US07407961B2

Reaction notes

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