Hydrochloric Acid → HCID 178456199, compound

HRID 2217257Notes

Reaction equation

HRID 2217257 reaction equation
[NH2:1][C:2]1[N:3]=[C:4]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:5]([C:10]2[CH:11]=[CH:12][C:13](=[O:19])[N:14]([CH:16]([CH3:18])[CH3:17])[CH:15]=2)=[N:6][C:7]=1[O:8]C.Cl>O1CCOCC1>[NH2:1][C:2]1[N:3]=[C:4]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:5]([C:10]2[CH:11]=[CH:12][C:13](=[O:19])[N:14]([CH:16]([CH3:18])[CH3:17])[CH:15]=2)=[N:6][C:7]=1[OH:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69103834HCID 69103834, compound

Product 1

HCID 178456199HCID 178456199, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 5-(5-amino-6-methoxy-3-phenyl-2-pyrazinyl)-1-isopropyl-2(1H)-pyridone (80 mg), conc. HCl (0.8 ml), and dioxane (1.6 ml) was heated with stirring at 100° C. for 3 hours. After cooling, the pH of the mixture was adjusted to 8 and a generated precipitate was isolated by filtration and dired in vacuo to give 5-(5-amino-6-hydroxy-3-phenyl-2-pyrazinyl)-1-isopropyl-2(1H)-pyridone (36 mg).

Workup

  1. temperaturewas heated
  2. temperatureAfter cooling
  3. customa generated precipitate was isolated by filtration and dired in vacuo

Sources & evidence

ORD record
ord-ca2f32c18634470cb815f74e0633f940
Source dataset
uspto-grants-2008_08
Patent number
US07407961B2

Reaction notes

Loading…