Triethylamine → HCID 11617070, compound

HRID 2217647Notes

Reaction equation

HRID 2217647 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[CH:10]=[CH:11]/[C:12]([OH:14])=O)=[CH:4][C:3]=1[O:15][CH3:16].Br.[OH:18][C:19]1[CH:20]=[C:21]([CH:24]=[CH:25][C:26]=1[OH:27])[CH2:22][NH2:23].C(N(CC)CC)C.CN([P+](ON1N=NC2C=CC=CC1=2)(N(C)C)N(C)C)C.F[P-](F)(F)(F)(F)F>>[OH:18][C:19]1[CH:20]=[C:21]([CH:24]=[CH:25][C:26]=1[OH:27])[CH2:22][NH:23][C:12](=[O:14])/[CH:11]=[CH:10]/[CH:9]=[CH:8]/[C:5]1[CH:6]=[CH:7][C:2]([OH:1])=[C:3]([O:15][CH3:16])[CH:4]=1

Participants

5

Reactant 4

HCID 8471TriethylamineHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 133435624-(Aminomethyl)benzene-1,2-diol--hydrogen bromide (1/1)HCID 14053117123022-35-5

Product 1

HCID 11617070HCID 11617070, compound

Procedure

The compound was prepared as described in Example 5 using 11 mg (0.05 mmol) of 5-(4-hydroxy-3-methoxyphenyl)-penta-2E,4E-dienoic acid [Example 3], 22 mg (0.10 mmol) of 3,4 dihydroxybenzylamine hydrobromide, 50 g (0.50 mmol) of triethylamine, and 33 mg (0.075 mmol) of BOP reagent.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-87604000bbc64962ab1479a7a98af203
Source dataset
uspto-grants-2008_08
Patent number
US07407989B2

Reaction notes

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