Dichloromethane → HCID 73989418, compound

HRID 2217661Notes

Reaction equation

HRID 2217661 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:9][S:10]([C:13]2[CH:14]=[C:15]([CH:19]=[CH:20][C:21]([OH:23])=O)[CH:16]=[CH:17][CH:18]=2)(=[O:12])=[O:11])[CH:6]=[CH:7][CH:8]=1.[Cl:24]CCl>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:9][S:10]([C:13]2[CH:14]=[C:15]([CH:19]=[CH:20][C:21]([Cl:24])=[O:23])[CH:16]=[CH:17][CH:18]=2)(=[O:12])=[O:11])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 67019645HCID 67019645, compound

Product 1

HCID 73989418HCID 73989418, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideCatalyst

Conditions

Temperature
40 °C

Procedure

To a suspension of 3-[3-(3-methoxyphenyl-sulfamoyl)-phenyl]-acrylic acid (5i) (0.38 g, 1.14 mmol) in dichloromethane (4 ml) oxalyl chloride (0.3 ml, 3.43 mmol) and one drop of dimethylformamide were added. The reaction mixture was stirred at 40° C. for one hour and concentrated under reduced pressure to give crude title compound (0.40 g, 100%).

Workup

  1. additionwere added
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-4c2201ac466343e08f6cb65e58d71780
Source dataset
uspto-grants-2008_08
Patent number
US07407988B2

Reaction notes

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