Hydrochloric Acid → HCID 11294414, Verbindung

HRID 2217792Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2217792
[Cl:1][C:2]1[C:3]([NH:26][C:27](=[O:35])[CH2:28][CH:29]2[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]2)=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH2:12][CH:13]1[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]1)[CH:6]=[CH:5]2.[ClH:36]>CO.ClCCl.O1CCOCC1>[ClH:1].[ClH:36].[Cl:1][C:2]1[C:3]([NH:26][C:27](=[O:35])[CH2:28][CH:29]2[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]2)=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH2:12][CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)[CH:6]=[CH:5]2

Komponenten

6

Edukt 2

HCID 313Hydrochloric AcidHCID 866097354-[[6-Chloro-5-[(cyclohexylacetyl)amino]-2-quinolinyl]methyl]-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester

Produkt 1

HCID 11294414HCID 11294414, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 887MethanolLösungsmittelHCID 6344DichloromethaneLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

4-[[6-Chloro-5-[(cyclohexylacetyl)amino]-2-quinolinyl]methyl]-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester (Example 1(b)) was dissolved in methanol (0.5 mL) and dichloromethane (3 mL). HCl in 1,4-dioxane (4M, 1 mL) was added and the mixture stirred for 1 hour. The resultant suspension was evaporated to dryness and recrystallised from methanol/ethyl acetate to give the title compound as a colourless solid (120 mg).

Aufarbeitung

  1. customThe resultant suspension was evaporated to dryness
  2. customrecrystallised from methanol/ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-31069971edc547c3b2537a3573f45718
Quelldatensatz
uspto-grants-2008_08
Patentnummer
US07408065B2

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