Hydrochloric Acid → HCID 11294414, compound

Participants

Reaction Steps

4-[[6-Chloro-5-[(cyclohexylacetyl)amino]-2-quinolinyl]methyl]-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester (Example 1(b)) was dissolved in methanol (0.5 mL) and dichloromethane (3 mL). HCl in 1,4-dioxane (4M, 1 mL) was added and the mixture stirred for 1 hour. The resultant suspension was evaporated to dryness and recrystallised from methanol/ethyl acetate to give the title compound as a colourless solid (120 mg).

Provenance & Evidence