3-Amino-1-propanol → HCID 11441306, compound

HRID 2217797Notes

Reaction equation

HRID 2217797 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:22])[C:8]=2[NH:12][C:13](=[O:21])[CH2:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[N:3]=1.[NH2:23][CH2:24][CH2:25][CH2:26][OH:27]>O>[ClH:1].[Cl:22][C:7]1[C:8]([NH:12][C:13](=[O:21])[CH2:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([NH:23][CH2:24][CH2:25][CH2:26][OH:27])[CH:11]=[CH:10]2

Participants

4

Reactant 2

HCID 90863-Amino-1-propanolHCID 86012996N-(2,6-Dichloro-5-quinolinyl)-cyclohexaneacetamide

Product 1

HCID 11441306HCID 11441306, compoundYield 40.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Prepared according to the method of example 2, using N-(2,6-dichloro-5-quinolinyl)-cyclohexaneacetamide (Example 1 (a)) (200 mg) and 3-amino-1-propanol (540 mg). Water was added to the residue and the product was collected by filtration. The product was converted to its hydrochloride salt by treatment with hydrochloric acid (4M in 1,4-dioxane). Recrystallisation (methanol/ethyl acetate) afforded the title compound as a solid (98 mg).

Workup

  1. customPrepared
  2. filtrationthe product was collected by filtration
  3. customRecrystallisation (methanol/ethyl acetate)

Sources & evidence

ORD record
ord-5baf9fef3f874f2287677445500c1e4c
Source dataset
uspto-grants-2008_08
Patent number
US07408065B2

Reaction notes

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