HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Dichloroquinolin-5-amine → N-(2,6-Dichloro-5-quinolinyl)-4-(trifluoromethyl)-cyclohexaneacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Dichloroquinolin-5-amine | HCID 24820374 | — |
| Reactant | 2-(4-(Trifluoromethyl)cyclohexyl)acetic acid | HCID 53414873 | — |
| Product | N-(2,6-Dichloro-5-quinolinyl)-4-(trifluoromethyl)-cyclohexaneacetamide | HCID 86609736 | 46% |
Reaction Steps
Prepared according to the method of example 1(a), using 2,6-dichloroquinolin-5-amine (prepared as described in Example 1(d) above) (400 mg) and 4-(trifluoromethyl)-cyclohexaneacetic acid (Example 8 (b)) (436 mg). Purification (SiO2, dichloromethane:methanol 99:1 as eluant) gave the sub-title compound (350 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07408065B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-c2e3f61709ca422cb12eec4ac5b4d59a |
| Source note | uspto-grants-2008_08 |